Regulatory data is for reference only. Always verify with the official regulator before making formulation decisions. Last refreshed: 8/29/2026.

Ingredients/1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III

1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex IIICAS 123-31-9

EU CosIng II — prohibitedEU CosIng III — restrictedFDA CFR 21 CFR 310.545 — restrictedASEAN II — prohibitedASEAN III — restricted

Regulatory status

Source	Status	Annex / Details	Limit / Conditions	Last updated
EU CosIng	prohibited	Annex II		—
EU CosIng	restricted	Annex III	0.02% (after mixing for use)	—
FDA	restricted	Annex CFR 21 CFR 310.545	No longer GRASE for OTC use as skin bleaching agent; requires prescription or reformulation. Prohibited from OTC drug marketing.	—
ASEAN	prohibited	Annex II	—	—
ASEAN	restricted	Annex III	0.02% (after mixing for use)	—

What this means

1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III has regulatory signals in EU CosIng, FDA, ASEAN. Review the source links above for the official conditions and latest updates.

Common questions

Is 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III restricted in EU cosmetics?: 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is prohibited in EU cosmetics according to EU CosIng Annex II.
Is 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III restricted by the FDA in the US?: 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is on the FDA's restricted substances list for cosmetics (CFR 21 CFR 310.545): No longer GRASE for OTC use as skin bleaching agent; requires prescription or reformulation. Prohibited from OTC drug marketing.
Is 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III restricted under the ASEAN Cosmetic Directive?: 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is prohibited under the ASEAN Cosmetic Directive Annex II.
What is the CAS number for 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III?: The CAS number for 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is 123-31-9.

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Regulatory status

Source	Status	Annex / Details	Limit / Conditions	Last updated
EU CosIng	prohibited	Annex II		—
EU CosIng	restricted	Annex III	0.02% (after mixing for use)	—
FDA	restricted	Annex CFR 21 CFR 310.545	No longer GRASE for OTC use as skin bleaching agent; requires prescription or reformulation. Prohibited from OTC drug marketing.	—
ASEAN	prohibited	Annex II	—	—
ASEAN	restricted	Annex III	0.02% (after mixing for use)	—

Common questions

Is 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III restricted in EU cosmetics?

1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is prohibited in EU cosmetics according to EU CosIng Annex II.

Is 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III restricted by the FDA in the US?

1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is on the FDA's restricted substances list for cosmetics (CFR 21 CFR 310.545): No longer GRASE for OTC use as skin bleaching agent; requires prescription or reformulation. Prohibited from OTC drug marketing.

Is 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III restricted under the ASEAN Cosmetic Directive?

1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is prohibited under the ASEAN Cosmetic Directive Annex II.

What is the CAS number for 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III?

The CAS number for 1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III is 123-31-9.